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Allying high-resolution with a large field-of-view (FOV) is of greatimportance in the fields of biology and medicine, but particularly challengingwhen imaging non-flat living samples such as the human retina. Indeed,high-resolution is normally achieved with adaptive optics (AO) and scanningmethods, which considerably reduce the useful FOV and increase the systemcomplexity. An alternative technique is time-domain Full-Field OpticalCoherence Tomography (FF-OCT), which has already shown its potential forin-vivo high-resolution retinal imaging. Here, we introduce curved-fieldFF-OCT, capable of matching the coherence gate geometry to the samplecurvature, thus achieving a larger FOV than previously possible. Using thisinstrument, we obtained high-resolution images of living human photoreceptorsclose to the foveal center without AO and with a 1 mm x 1 mm FOV in a singleshot. This novel advance enables the extraction of photoreceptor-basedbiomarkers with ease and spatiotemporal monitoring of individualphotoreceptors. We compare our findings with AO-assisted ophthalmoscopes,highlighting the potential of FF-OCT, as a relatively simple, compact andlow-cost system, to become a routine clinical imaging technique.

Curved-Full-Field OCT for high-resolution imaging of living human retina over a large field-of-view