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The space-variant wavefront reconstruction problem inherently exists in deeptissue imaging. In this paper,we propose a framework of Shack-Hartmannwavefront space-variant sensing with extended source illumination. Thespace-variant wavefront is modeled as a four-dimensional function where twodimensionsare in the spatial domain and two in the Fourier domain with priorsthat both gently vary. Here, the affinetransformation is used to characterizethe wavefront space-variant function. Correspondingly, the zonaland modalmethods are both escalated to adapt to four-dimensional representation andreconstruction.Experiments and simulations show double to quadrupleimprovements in space-variant wavefront reconstruction accuracy compared to theconventional space-invariant correlation method.

Space-variant Shack-Hartmann wavefront sensing based on affine transformation estimation