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Nickel(I1) macrocyclic complexes have been found to promote site- and conformation-specific oxidation of DNA. The systematic study of ligand effects has demonstrated that the crucial features in regulating DNA reactivity are in-plane donor strength and flexibility of the macrocyclic ligand. Based upon investigations of conformation specificity, macrocyclic ligand effects, and oxidant requirements, a mechanism has been proposed.' In this mechanism, a nickel(II1) complex containing a ligated guanine and oxidant molecule is postulated as a key intermediate. The oxidation of DNA has also been extended to macrocyclic complexes containing cobalt(III), rhodium(II1) and chromium(II1).

Macrocyclic nickel complexes in DNA recognition and oxidation