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Utilizing my clinical experience with cases of beryllium disease, together with data accumulated in a registry of patients in the United States with beryllium poisoning) and the reports in the literature) I want to discuss the problem of beryllium poisoning and its control by keeping exposures at, or below, certain existing target levels. In the United States, there are in current use three separate figures for the control of harmful effects of toxic beryllium compounds and) as far as I know, this is unique in industrial hygiene practice. These figures were proposed in 1948 by an advisory committee appointed by the Division of Biology and Medicine of the United States Atomic Energy Commission, of which I have been a member and all through its deliberations. The figures were recommendations intended for the prevention of beryllium disease at atomic energy laboratories only, but gradually they came into fairly wide usage. For a variety of reasons, in spite of impressive evidence of disability and death among certain groups of beryllium-exposed workers, there has been to date no definite action by industrial or government groups to adopt either the figures used by atomic energy projects or any other figures as maximum allowable concentration (M.A.C.) for toxic beryllium compounds. In April 1958, the Beryllium Advisory Committee (as this group was named) voted to disband, hoping thereby to encourage policy-making industrial hygiene groups to adopt or modify these proposed safe levels for toxic beryllium exposure. The Beryllium Advisory Committee had in its membership an industrial hygienist, a toxicologist) two physicians and, from time to time, consultants especially experienced with occupational disease were called on for advice. After initial deliberations, the Committee met annually to review new knowledge and to modify, if need be, the target levels for beryllium exposure tentatively suggested in 1948. At the insistence (wisely, I believe) of one member, it was agreed that the proposed safe beryllium levels should have the sanction of the Committee for only one year at a time. This was an attempt to keep the figures flexible so that if added data suggested that a change was necessary this could be achieved promptly. All of us interested in M.A.C.'s know how easily figures suggested in the literature as safe take on almost the, force of law and rapidly become impossible to change. I want to examine with you these three proposed levels of beryllium

Experience in the United States with proposed safe levels of exposure to toxic beryllium compounds