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In this retrospective study; we evaluate cardiac disorders and systemic hypertension in JAK2 V617F positive patients. We identified 1000 patients in our hospital system that had been evaluated for JAK2 V617F mutation. Among these patients we found 100 JAK2 V617F positive patients and 100 JAK2 V617F negative patients matched by age and gender. Cardiac disorders were characterized as coronary artery disease (CAD), atrial fibrillation (Afib), heart failure (HF), and myocardial infarction (MI). As well as cardiac disorders and systemic hypertension (HTN), we considered the other thrombotic events such as stroke, deep vein thrombosis (DVT), pulmonary embolism (PE) and peripheral arterial disease (PAD). We conclude that there is an association between JAK2 V617F mutation and HTN, CAD, DVT, PAD, HF and Afib.

The Evaluation of Cardiac Disorders and Systemic Hypertension in JAK2V617F Positive Patients at a Multicenter Institution