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Objectives: The objective of this study was to determine the effects of 12-week honey oral supplementation on fasting serum lipid profiles among chronic smokers. Design: This study was a randomized, controlled, open-label clinical trial design. Settings/location: Quit Smoking Clinic, University Sains Malaysia (USM) Hospital and Health Campus USM. Subjects: Participants from non smokers (n=32) and chronic smokers (n=64) aged between 20 – 50 years old were recruited. Participants from smoker group should have smoked at least 10 cigarettes per day for more than 5 years. Interventions: The chronic smokers were further randomized into 2 groups namely smoker without honey (n=32) and smoker with honey (20 g/day) for 12 weeks (n=32). Outcome measures: Outcome measures were triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol (TC) levels between non smokers and chronic smokers at pre-intervention as well as the differences of these parameters between pre and post-intervention among smoker without honey and smoker with honey groups. Results: At pre-intervention, chronic smokers had significantly lower HDL and higher TG, LDL and TC levels than non smokers. In smoker with honey group, TC and LDL levels were significantly reduced at postintervention than at pre-intervention. No significant changes were found in smoker without honey group. Conclusion: This study may suggest that honey supplementation improves lipid profiles in chronic smokers which in turn may reduce the subsequent risk of cardiovascular diseases.

An Open-Label Pilot Study to Assess Honey Supplementation in Improving Lipid Profiles Among Chronic Smokers