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S.typhi ompSI constitutes a novel porùt gene. It has seven putative OmpR-binrling boxes and three promoters. Our current model for expression contempLates activation of transcription, from Pl, by OmpR-bindùtg to boxes II anct III (Ctype, low affinity); whereas boxes I and IV-VII would be ùwolved in negative regulation. The fact that ompSI expression increases more thayt 100-foçt upon removal of the cis-acting elements, and that this level is more than l}-foLd ltigher than that for ompC, which codes for a major porin, raises interestirtg questions on its role and regulation in nature. The analysis of the expression of S. typhi ancl E. coli ompC-lacZfusiotts, in cross-complementation experiments with either the S.tylthi or E. coli omp B (ompMenvZ) operons, in either S.typhi or E.coli ompB backgrouttds, showed that both S. typhi and E coli ompC are not regulated by osntolarity when th.ey are under the control of.S.tltphi ompB i, S. typhi' Interestingly, in an S. typhi backgrountl , both genes are osmoregulated under E. coli ompB. In contrast, in E.coli, they are botlt osmoregulated untler S. typhi or E,coLi ompB. ThtLs, the lack of osmoregulation of S.typhi ompC expressiol, is determi1ecl both by ttte S,typhi ompB operon and by otlrcr unknown factors presetxt in S.typhi. Suppl I 1998 Novel Porin genes and modes of Porin regulation Tlphoid Fever and other Salmonellosis" Typhoid fever (TF) is still a major healrh problem throughout the developing world; it is estimated that there are 16.6 million cases annually, with nearly 600 thousand deathsl,2. S. typhi, the causal agent of TF, causes a septicemia in man; while S. typhimurium causes a typhoid-like infection in mice. Thus, new knowledge on S.typhi virulence and on the immune response during TF, should allow the design of improved procedLlres for the control and prevention of the disease, especially in poor areas of the world3. Moreover, the new information should be of use towards a global understanding of the molecular pathogenesis of other salmonellosis, on the rise v/orldMolecular Biology and Genome 25

Novel Porin genes and modes of Porin regulation in <em>Salmonella typhi</em>