Creatinine and renal function in children

In most clinical conditions, the rate of creatinine synthesis remains constant and its plasma concentrarton retlects the rate of renal elimination. To lmow how far the kidneys have been damaged the renal function in children suffering f'rom renal diseases must be measured. The aim of this study was to measure plasma creatinine concentrations (Pc) and renal function or glomerular filtration rates (GFR) expressed by inulin clearance (Ciil and cleatinine clearance (Cq) in children suffering from renal diseases, and to know how would be the correlation between them. In this cross-sectional study sample size was estimated by the one-sample for estimating the population proporrton, and dan analyzing was done by the Pearson Product Moment Correlation. Simultaneous measurements of Cin andCctleyelsin 112 childrenwere done oyer theperiodfromMarch 1991 n JuIy 1993. Resultof this sudy showedtherewas ahyperbolic negative correlation between Pç1 and GFR in all children with mixzd (normal and decreased) renal functions ; Pcr 4.34 0,03 Cin (r = -0.58; p < 0.001 ; N = I 12) and Pcr = 4.72 0.03 C$ (r = -0.60; p < 0.001 ; N = I 12) Keyworils: Plasma creatinine, Inulin and creatinine clearances, Children