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Atherosclerosis and coronary heart disease are predicted to be prominent health problem in the next few years in Indonesia. High blood Iipid level is considered to be among the iskfactors. It can be controlled by medication and dictary mea.sures. Tempe, a highly nutricious food, is known to contain many substances that could influence blood lipid level. This study was conducted to investigate the influence of tempe, and factor 2, an antioxidant found in tempe, on the blood lipid level of rabbits maintained with a high intake of cholesterol. Tempe was given 6.2 g/kg BWday. The results of this study shows that tempe inhibit further increase of cholesterol, and decrease total cholesterol level by 19.LVo, LDL cholesterol by 49.2Vo, HDL cholesterol by 25,2Vo. The group receiving factor 2 showed a decrease of total cholesterol by I8.9Vo, I'DL cholcsterol for 40.3Vo and HDL cholesterol by 62Vo. The combination of tempe and factor 2 cause a decrease in total cholesterol by 20.2Vo, HDL cholesterol by 52.47o, but increase the LDL cholesterol by 24.5Vo" It appeared that tempe gave the best result in changing the blood lipid pattem. Further sntdies on the effect of ways of cooking (fry, steam, barbeque, boil) to the ability of tempe in decreasing blood lipid level, and the amount/ dosage to be talcen is suggested, since those are the foims that are usually consumed.

Tempe and changes of cholesterol pattern in hyperlipidemic rabbits