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?o assess the relationship between Histology Activitiy Index (HAI) and the expression of HBsAg and HBcAg. Thirty liver biopsy specintens ofchronic B hepatitis patients have been exanined Expression of HBsAg and HBcAgwere determined by imtnunoperoxidase staining. HAI was calculated according to Knodell's ntethod. All of the specimens (29) were positive for HBsAg and HBcAg staining. Regular-unifonn disÛibution patterns of HBsAg were found in 3 specinens and irregular non-uniforn patterns in 26 specinens . Regular-unifonn panerns of HBcAg were found in 4 specinens and the irregular non-uniforn patterns in 25 specimens. HBsAgs I + were seen in all specinens which have HAI range of I to 18. Cytoplastniy'nenbraneous HBcAgs were seen 1+ in 20 specitnens, 2+ itt 3 specitnens, and i+ in 6 specinens. HAI of each group which showed HBcAg was not significantly dfurent. HBcAgs in the nuclei of Iiver cells were seen I + in 14 specinens, and 15 specinrens were negotiveHAI of each of these groups showed no significant dffirences. HAI of regular-uniform distribution pattern groups of HBsAg and HBcAg were not significantly different from HAI of irregular non-uniform groups.: Expression of HBsAg and HBcAg in liver biopsy specinens.of chronic B hepatitis patients are not correlated with ne c r oinflantmatory ac tivity.

Expression of HBsAg and HBcAg in liver biopsy specimens of chronic B hepatitis patients and its relation with histology activity index