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Polyamines are essential for diverse biological functions in prokaryotic and eukaryotic cells. Both endogenous synthesis and uptake by means of active transport mechanisms provide the pool of intracellular polyamines. Cancer cells rely on polyamine levels to proliferate, thus interrupting key aspects of polyamine metabolism may serve to impede tumour growth. This overview focuses on the latest findings that relate to the polyamine uptake pathway in the yeast model system, and which may help to refine the development of novel therapeutics to retard cancer growth. Conclusion We believe that there are inherent complexities within the polyamine uptake pathway and that a detail understanding of this process would lead to the precise targets.

Agp2: A master regulator of polyamine uptake that signals gene expression