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- The present study was evaluated the antibacterial effect of the combination of Coptidis rhizoma,Glycyrrhiza uralensis Fischet, Schizandra chinensis and Corni Fructus(1:1:1) extracts(CGSC10). Furthermore, theeffectiveness of CGSC10, sodium chlorate, and the combination of CGSC10 and sodium chlorate(CGSCS10) againstE. coli O157:H7 infection was studied using ICR female mice. During the incubation period, the dose of 5, 10, and20% CGSC10 was inhibited the growth of E. coli O157:H7 by 34.7, 60.2, and 76.4%, respectively. For 7 days aftersingle challenge with E. coli O157:H7, forty female ICR mice were divided into four experimental groups which wereadministered in drinking water with saline, 10% CGSC10, 15 mM sodium chlorate, and CGSCS10, respectively. Onthe 3rd day, the number of E. coli O157:H7 in mouse feces was significantly decreased by administration of CGSC10,15 mM sodium chlorate, and CGSCS10 (p < 0.001). On the 7th day-after administration, CGSC10, sodium chlorate,and CGSCS10 were decreased the number of E. coli O157:H7 by 27.1, 67.7, and 83.3%, respectively. According tothe results of the present study, administration of CGSCS10 to mice can reduce the severity of E. coli O157:H7 infec-tion. In addition, it is suggested that CGSCS10 represents a good candidate for the treatment of enteric infections indomestic animals. Key words: Korean traditional herbal extracts, sodium chlorate, antibacterial activity, E. coli O157:H7

Antimicrobial Activity of Sodium chlorate and Korean Herbal Extracts against Mice infected with Escherichia coli O157:H7