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We report the case of a 72-year-old man with 2 simultaneous gastric carcinomas. The larger, ulcerated mass in the antrum was a conventional infiltrating intestinal-type adenocarcinoma. The associated antral-type mucosa showed moderate chronic gastritis, foci with complete and incomplete intestinal metaplasia, and mild to moderate Helicobacter pylori infection. The second, smaller tumor was found within fundic-type mucosa and was a lymphoepithelioma-like carcinoma associated with Epstein-Barr virus (EBV) infection shown by the EBV-encoded small RNA (EBER) test. The EBER test result was negative in the intestinal type adenocarcinoma. To our knowledge, this is the first report of simultaneous gastric carcinomas with 2 different morphologic phenotypes, in which only one tumor was associated with EBV infection, while the second tumor was related to H pylori-associated chronic gastritis. Our report demonstrates 2 different but simultaneous etiologic pathways of gastric carcinogenesis in the same patient.

american journal of clinical pathology

Simultaneous EBV-Positive Lymphoepithelioma-like Carcinoma and EBV-Negative Intestinal-Type Adenocarcinoma in a Patient With<i>Helicobacter pylori</i>–Associated Chronic Gastritis

Simultaneous EBV-Positive Lymphoepithelioma-like Carcinoma and EBV-Negative Intestinal-Type Adenocarcinoma in a Patient WithHelicobacter pylori–Associated Chronic Gastritis