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1. What are this patient’s most striking clinical and laboratory findings? 2. What is unusual about these findings? 3. How do you explain these findings? 4. What additional laboratory test could be performed to confirm your explanation of these findings? 5. What are some of the ways in which the problem that led to this patient’s spuriously increased total prostate-specific antigen (TPSA) concentration can occur? 6. What are some of the ways in which laboratories and manufacturers of diagnostic immunoassays can resolve the problem that led to this patient’s spuriously increased TPSA concentration? 7. How effective are the different approaches to identifying and/or resolving the problem that led to this patient’s spuriously increased TPSA concentration? 8. What is the incidence of the problem that led to this patient’s spuriously increased TPSA concentration? 9. Can adverse consequences occur when the problem that led to this patient’s spuriously increased TPSA concentration is unrecognized? 10. Is the problem that led to this patient’s spuriously increased TPSA concentration reversible?

Persistently Elevated Prostate-Specific Antigen Level After Successful Laparoscopic Radical Prostatectomy