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Formalin-fixed, paraffin-embedded unstained archived diagnostic tissue sections are frequently exchanged between clinical laboratories for immunohistochemical staining. The manner in which such sections are prepared represents a type of preanalytical variable that must be taken into account given the growing importance of immunohistochemical assays, especially predictive and prognostic tests, in personalized medicine.

american journal of clinical pathology

Canadian Association of Pathologists–Association canadienne des pathologistes National Standards Committee for High Complexity Testing/Immunohistochemistry