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The aim of this study was to know the hypoglycaemic and hypolipidaemic activities of water extract of bungur (Lagerstroemia speciosa [L.] Pers.) leaves in alloxan-induced diabetic rat. Phytochemical studies was conducted to determinate the tannin-contents of the water extract (WE). Male Wistar rats (150- 180 9 BW) were used in this study. The rats were divided into six groups: nonnal control; diabetic control; glibenclamide; WE 0.1 g/200 9 BW; WE 0.2 g/200 9 BW; and WE 0.5 g/200 9 BW. Dried leaves of bungur extracted with boiling water (50 g/L) for 30 minutes. The extract administered orally. Fasting blood glucose, triglyceride, and total cholesterol were determined at 0, 2, 4, 6 hours after treatment. Total phenol, ellagitannin, gallotannin, and condensed-tannin were determined from the WE. The results showed that WE exhibited hypoglycaemic activity at doses 0.2 g/200 9 BW and 0.5 g/200 9 BW. The last dose showed similar hypoglycaemic activity compared with glibenclamide. All doses showed the hypolipidaemic activity higher than glibenclamide. Phytochemical studies showed that the WE containing total phenol 0.025%; ellagitannin 0.011%; gallotannin 0.0199%; and condensed-tannin 0.0167%.

Hypoglycaemic and hypolipidaemic activities of water extract of Lagerstroemia speciosa (L.) Pers. leaves in diabetic rat