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Description: The diagnosis and classification of COPD can be seen as the difficult task of describing a heterogeneous disease affecting a complex organ, using relatively simple measurements. Combining these measurements and thus describing the impact of disease on the lung and its functional capacity can provide additional information enabling the clinician to succeed in this task. In this context, this thesis has investigated the clinical description of pulmonary gas exchange abnormalities, the current standard (DLCO), the reference experimental technique (MIGET), and a new alternative (ALPE). The aim of the thesis has been to investigate the challenges ALPE faces in patients suffering from COPD (paper I) and if possible to present and evaluate new methods to overcome these challenges (paper II). Furthermore, integration of ALPE with routinely available clinical measurement and its relation to HRCT-scans was evaluated (paper III).

The Application of a New Tool for Evaluation of Lung Function in COPD