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Platelet-rich plasma (PRP) is being used increasingly often in the clinical setting to treat tendon-related pathologies. Yet the optimal PRP preparations to promote tendon healing in different patient populations are poorly defined. Here, we sought to determine whether increasing the concentration of platelet-derived proteins within a derivative of PRP, platelet lysate (PL), enhances tenocyte proliferation and migration in vitro , and whether the mitogenic properties of PL change with donor age.

Platelet lysates from aged donors promote human tenocyte proliferation and migration in a concentration-dependent manner