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The interaction studies of drug ciprofloxacin with two mixed micellar systems are reported. The mixed micelles comprise a nonionic hydrophobic surfactant, pluronic L-81, an anionic surfactant, Ammonium dodecyl sulfate (ADS); and a cationic surfactant, Cetylpyridinium bromide (CPB). The various combinations chosen were L-81-ADS and L-81-CPB. The properties of both the mixed micelles were compared. Spectrophotometric, conductometric, co-solvent effect, and Infrared studies were used for the investigations. The studies were carried out in a wide range of mixed micellar concentrations in the post micellar region of the individual surfactants. The solubilization of drug CPX in the L-81-ADS was higher than that in L-81-CPB mixed micelle, as evidenced by UV studies. Ethanol and ethylene glycol were found to be effective co-solvents for both the mixed micellar systems. The conductivity studies of CPX with ADS and CPB surfactants, displayed a higher value of conductance for CPX and ADS, from 0.37µs-1 to 0.74µs-1 compared to CPX and CPB. The drug-mixed micelle displayed a higher molecular weight complex formation as seen from the IR spectra.

Comparison Between Interaction of Hydrophobic-anionic and Hydrophobic-cationic Mixed Micellar System with Drug Ciprofloxacin