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The stability constant Kf for the complexation of Ag(I) metal ion with Midodrine hydrochloride were determined by spectrophotometric method at room temperature .The colored complexes were measured at 300 nm. The stability constant of the complexes were found to be 5.47 by mole ratio method. The stoichiometry of the complexes formed between the Midodrine drug and Ag (I) metal ion are 1:1 M/L ratio. Silver conjugated Midodrine hydrochloride Nano synthesized and characterized by UV-Visible spectroscopy, SEM, XRD and FT-IR. The UV-Visible spectra of Midodrine -Ag nanoparticle in the range of 322 nm. XRD conform The crystallite size of Midodrine -Ag (I) nanoparticles are found to be 64.5 nm from Debye Scherer formula. The crystallinity of nanoparticles is Face centered cubic structure. SEM conform of particle size and surface morphology, FTIR analyzed involvement of -NH2 group in Midodrine is the stabilized of silver nanoparticle. This research is focuses on complexation, Nano synthesis and characterization of Drug-silver nanoparticle for antihypotention therapy.

Nano Synthesis and Characterization of Complex Derived from Silver Metal Conjugated with Midodrine Hydrochloride