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Many medicinal plants have been used to treat and prevent illnesses in Saudi Arabia. The present study aimed to investigate the chemical composition of Mentha viridis obtainedfrom Albaha region of Saudi Arabiaand evaluate its antimicrobial and antiproliferative potential. The extract was obtained from plant fresh material and identified by gas chromatography-mass spectrometry (GC-MS). The antimicrobial and antiproliferative potential of the plant extract was analysed by performing four subsequent extracts: ethanol, petroleum ether, chloroform, and methanol. The GC-MS analysis showed carvone as a main component, as it comprised 64.82 % of the plant extract. In antimicrobial activity, methanol extract showed significant activityagainst Pseudomonas aeruginosa with zone of inhibition of 15 mm. The MTT assay showed thatpetroleum ether and chloroform extracts have moderate cytotoxic effect against MCF-7 breast cancer cell line with IC50 values of 193.23 μg/mL and 131.86 μg/mL, respectively. Chloroform extract also showed mild activity against HCT-116 colorectal cancer cell line with IC50value of 189.2 μg/mL. This study highlights the potential of M. viridis extracts as powerful bioactive phytochemicals with possible role in diseases and cancer therapy.

Chemical Composition, Antimicrobial Activity and Potential Cytotoxic Effect of Mentha Viridis (Spearmint) Extracts from Saudi Arabia