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In the present research we have reported simple efficient synthesis technique to afford a novel series of 3-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)-N-aryl-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazol-6-amine (4a-g) derivatives obtained by one pot cyclocondensation reaction of 5-(5(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)-4-amino-4H-1,2,4-triazole-3-thiol (3) with substituted aryl isothiocyanate in DMF and K2CO3, without formation undesirable side products by simple work up procedure. The structures yielded (4a-g) were established by 13CNMR, IR, 1HNMR, elemental analysis and mass spectra. Entire synthesised compounds were screened for their In vitro biological assay via microorganism Gram-positive and Gram-negative bacterial strains at different concentrations. The bioassay revealed that some of the compounds have promising antimicrobial activities when compared with standard drug Chloramphenicol.

Facile Synthesis, Characterization and Antimicrobial Activities of Novel 6-AminoTriazolo-Thiadiazoles Integrated with Benzofuran and Pyrazole Moieties