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Methyl-5-(hydroxymethyl)-2-furan carboxylate and derivatives were prepared from furfuryl alcohol and their biological activities were studied for cytotoxicity against cancer cell lines HeLa, HepG2 and Vero, and Gram (+) and Gram (-) bacteria. The amine derivative, (5-(((2-(1H-indol-3-yl) ethyl)amino)methyl)furan-2-yl)methyl acetate was found to have the most potent biological activity with IC50 62.37 μg/mL against the HeLa cell line and MIC 250 μg/mL against the photogenic bacteria.

Synthesis and Biological Activity Studies of Methyl-5-(Hydroxymethyl)-2-Furan Carboxylate and Derivatives