English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The discovery of antiviral drugs is developing new alternative medication and economics prices. One of the natural resources for alternative medicine is the water extract of faloak stem bark which is a material used by Kupang Community as an antiviral drug. The HCV JFH1 lifecycle inhibition is expressed in IC50 (inhibitory concentration 50%) and the toxicity of water extract of faloak stem bark in hepatocyte cell line Huh7it is expressed in CC50 (cytotoxicity concentration 50%). Determining the results obtained using Microsoft Office® Excell 2013®. The water extract of faloak stem bark has an inhibition of HCV genotype 2a strain JFH1 with the IC50 11.57 μg/mL and the toxicity water extract of faloak stem bark in the Huh7it cell line hepatocyte with the CC50 >1000 μg/mL. Mode of action activities from water extract of faloak stem bark can be inhibited all step HCV life cycle. The first step is entry step has the inhibition 93.97%, post-entry step has the inhibition 96.75%, and combination step (entry and post-entry step) has the inhibition was 100%. The active compound in the water extract of faloak stem bark was epicatechin 875 mg/kg. The water extract of faloak stem bark can be a candidate for antivirals against HCV JFH1.

Faloak (Sterculia Quadrifida R.Br) Stem Bark Extract Inhibits Hepatitis C Virus JFH1