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The research includes a clinical study of Preptin with other parameters. The normal value of preptin in hypothyroidism (2638.4 ± 280.0) in female while (2960.4 ± 256.6) in male, in hyperthyroidism (589.0 ± 90.1) in male, while in female (993.2 ± 103.9), diabetes (2465.6 ± 282.4 ) in female, in male (2085.5 ± 282.8), in diabetes & hypothyroidism (3314.3 ± 177.3) in male, (3179.4 ± 265.7) in female, but control group in female (427.8 ± 60.4), in male (384.7 ± 62.4) at age (20-45) years they were divided into five groups: group one (G1) consisted of 30 hypothyroidism. The two group (G2) consisted of 30 patients with hyperthyroidism. And three group (G3) consisted of 30 healthy group, four group (G4) consisted of 30 patient with diabetes, and five group (G5) consisted of 30 patient with diabetes & hypothyroidism. The result show BMI where the results showed higher females compared with male in all groups, and a rise in the TSH in hypothyroidism and diabetes & hypothyroidism compared with other group, while shown low result in hyperthyroidism compared with other groups. But calcium, vitamin D3, FSH, and LH were nonsignificant because of people with osteoporosis and heart disease were excluded as did women with multiple polycystic ovaries. The aim of this study is to estimate the efficacy of preptin hormone for thyroid patients with diabetes. keywords: Preptin, Thyroid dysfunction, Diabetes mellitus,

Estimation of Preptin in Serum of Thyroid dysfunction Patients and its Relationship with other Parameters