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A simple, fast and efficient validated method is developed for determination of magnesium content in Esomeprazole-Magnesium by using atomic absorption spectrophotometer (AAS) with 0.2 nm slit width with high speed deuterium (D2) lamp. The read time was set at 3.0 second with 285.2 nm wavelength. The system performance was evaluated by performing the system suitability parameters. The limit of detection and limit of quantification were found to be 0.01 μg/mL and 0.03 μg/mL respectively. The percentages of recovery for low, medium and high spiked concentration levels of magnesium in Esomeprazole-Magnesium were found to be 91.85, 95.02 and 97.89 respectively. With the developed method the magnesium content in Esomeprazole-Magnesium bulk sample was found to be 3.48 % which compliance the United States Pharmacopoeia standard.

Method Development and Validation for the Estimation of Magnesium Content in Esomeprazole Magnesium by Atomic Absorption Spectrophotometer