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A rapid HPLC bio-analytical method has been developed and validated for the simultaneous quantification of Ombitasvir (OMBTSR), Ritonavir (RTNVR), Paritaprevir (PTVR) in human plasma. OMBTSR and PTVR are used to control Hepatitis-C infection. RTNVR is used in the treatment of HIV/AIDS. The method was developed with Column (Intersil ODSC 18, 250 mm × 4.6 mm × 5μ) at 230 nm wave length and at flow rate of 1.0 mL/min. The mobile phase consisted of 20% Acetonitrile, 20% Methanol, 60% 1mM NH4H2PO4Buffer(P H 6.5 v/v). The retention times of RTNVR, OMBTSR, PTVR are 5.7 min. 7.8 min. and 12.8 min. respectively. The method was developed and validated in terms of linearity, interday precision, intraday precision, accuracy, LOQ, LOD and stability study. The proposed method is useful in pharmacokinetic studies using HPLC or LC-MS.

oriental journal of chemistry/oriental journal of chemistry

New Analytical HPLC Method Development and Validation for the Simultaneous Quantification of Paritaprevir Ombitasvir and Ritonavirin Spiked Human Plasma.