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Vancomycin hydrochloride (VCM) is a glycopeptides antibiotic. We intend to optimize preparation condition of VCM nanoparticles. Nanoparticles have high bioavailability and oral absorbable fraction. After drug to polymer ratio optimization, loading efficiency, production yield and particle size were measured by changing the organic phase volume, aqueous phase volume and emulsifier concentration in selected formula. DSC, XRD, FTIR, dissolution rate, and zeta potential were surveyed. The mean particle size, percentage of loading efficiency and production yield for selected formula were 430 nm, 89% and 98% respectively. Particle size has been inversely associated with most evaluated independent factors. Loading efficiency and production yield had inverse correlation with organic phase volume and with the rest of factors had linear correlation. keywords: Vancomycin, VCM, Double emulsion, Eudragit RS-100, Nanoparticle.

Preparation of Vancomycin Hydrochloride Nanoparticles and Survey of the Factors Influence their Properties