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In this work Cefotoxime (CFX) and its Cd (II) and Cu (II) metal complexes determination were carried out by spectrophotometric method. The following experimental procedures like effect of pH, effect of metal ion concentration, effect of drug concentration, effect of time, effect of organic solvents and the composition of the complex by mole ratio and job’s continuous variation method and interference studies were carried out for the determination of metal ions and drug. In this research work, it is clear that Cd forms a stable 1:1 colored complex with CFX in basic medium and Cu forms stable 1:1 colored complex with CFX in acidic medium. Effect of pH was studied for CFXCd (II) and CFXCu (II) complexes; it is noticed from that at pH 11 CFXCd (II) and at pH 5.5 CFXCu (II) colored complexes were formed. In these reactions can be found the metal ions in the range 1.12 to 6.74 and 3.812 to 8.895 μg/ml and the drug in the range 0.02 to 0.14 mg/ml respectively for CFXCu (II) and CFXCu (II) complexes. Effect of time clearly suggest , that the maximum absorbance is obtained only after heating the mixture to 40o & 60°C respectively for CFXCd (II) and CFXCu (II) complexes. It has been observed that the absorbance values remain constant thereafter; it indicates the formation of 1:1 stable metal complexes.

Spectrophotometric Determination Studies of Cefotaxime (CFX) and their CFX- Cd (II) and CFX- Cu (II) Complexes