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The search for potent chemotherapeutic agents with anticancer activity and issued from natural sources is still attracting a wide interest as drug-resistance tends to proliferate.The synthesis of alkaloids, which has been described in excellent reviews has little been explored if one except the largely investigated area of the catharanthus roseus alkaloids1,2. More recent work on indole alkaloids has focused on the complex haplophytine which has finally succumbed recently to total synthesis. However, recent work by Kam, Morita and coORIENTAL JOURNAL OF CHEMISTRY

oriental journal of chemistry/oriental journal of chemistry

A Facile Protocol for the Construction of Tricyclic Framework Tetrahydrobenzo-4-nitrobenzenesulfonate, 4-methylbenzenesulfonate and [1,8] naphthyridine Substituents from Methyl δ-Lactam