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There are studies which indicate that some heterocyclic derivatives have inotropic effect; nevertheless, its inotropic activity is very confusing perhaps to difference in the chemical structure. In order, to clarify these phenomena in this study, some pirrol-indol derivatives (compounds 3, 4, 5 and 6) were synthesized with the objective of to evaluate its biological activity using a biological model. The results indicate that only the compound 4 induce a positive inotropic activity in comparison with the compound 3, 5 and 6. This datasuggest that the different groups involved in the chemical structure of 4 arethe responsible of its positive inotropic activity. In addition, this phenomenon its conditioned by some physicochemical parameters such as LogP, σ, Vm, Rm, Pc and St,which are cumulative effects of the different intra-and intermolecularforces involved in the structural chemistry of the compound 4.

Design and synthesis of a new pirrol-indol derivative with positive inotropic activity.