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Synthesis of 4-[(2/4-chloro-/2,3-dichloro-/2/4-bromo-/2,4-dinitro-/4-nitrophenyl) anilinemethyl]6-t-butyl-2H-1-benzopyran-2-ones have been carried out. Synthesized compounds were characterized by 1 HNMR, IR and other physical and analytical data. All of the synthesized compounds were evaluated for their antifungal activity against Aspergillus awamori and Sclerotium rolfsii and antibacterial activity against a bacterium of Bacillus species in vitro at 10, 50, 100 and 200 µg/ml concentrations. Compounds 4-[(2-chlorophenyl)anilinomethyl]-6-t-butyl-2H-1-benzopyran-2-one(11) and 4-[(4chlorophenyl) anilinomethyl]-6-t-butyl-2H-1-benzopyran-2-one(12) exhibited good antifungal activity among tested compounds. Compound 4-[(2-bromophenyl) anilinomethyl]-6-t-butyl-2H-1-benzopyran2-one(14) showed significant antibacterial activity against the test bacterium.

Synthesis and Bioevaluation of 4-[(2/4-chloro-/2, 3-dichloro-/2/4-bromo-/2, 4-dinitro-/4-nitrophenyl) Anilinomethyl]-6-t-butyl-2H-1-benzopyran-2-ones