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Condensed der iva t ives o f 1 ,3 ,4 thiadiazolo[3,2a]pyrimidinewere reported to possess a broadspectrum of biological activity1-4, including antibacterial,antitumor, fungicidal, and herbicidal properties. However,thiadiazoles and their condensed analogs are still in sufficiently studied. In continuation of the search for substances possessing increased ability to permeate through biologicalmembranes of various infectious species 5 – 7 and, in particular, for the new antibacterial drugs in these homologousseries of compounds. ORIENTAL JOURNAL OF CHEMISTRY

Reaction 2-R 5-oxo 5-H 6-Ethylcarboxylate 7-phenyl-1 ,3,4-thiadiazolo- [3,2-a] pyrimidine with Amin