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A simple and specific second-order-derivative spectorophotometric method has been developed and validated for simultaneous quantification of atorvastatin calcium (ATV) and fenofibrate (FEN) in tablet dosage forms. ATV was determined at a wavelength of 281 nm (zero-crossing wavelength point of FEN). Similarly, FEN was measured at 296 nm (zero-crossing wavelength point of ATV) in phosphate buffer, pH 2.8 as solvent. The second derivative amplitude-concentration plots were rectilinear over the range of 2-12 µg/mL for ATV and 1-30 µg/mL for FEN. The % assay in commercial formulation was found to be in the range 98.8 - 102.5 for ATV and 99.6 - 100.25 for FEN by the proposed method. The method was validated as per ICH guidelines. The proposed method can be effectively applied for routine analysis of ATV and FEN in tablets.

oriental journal of chemistry/oriental journal of chemistry

A Validated Spectral Discriminating Derivative Spectrophotometric Method for Simultaneous Quantification of Atorvastatin calcium and Fenofibrate Combination in Tablets