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Transrectal ultrasound-guided prostate biopsies (TRUSBx) are common and increasingly performed procedure. As this procedure can be complicated by infections, antibiotic prophylaxis is widely used around the world to minimize these complications, but there is no consensus on the most appropriate prophylaxis regimen. A total number of 412 patients who were referred fo TRUSBx, was devided randomely into two groups. Group 1 received routine antibiotic prophylaxis and Group 2 did not received Amikacin. Other premedications in both groups include ciprofloxacin, metronidazole, ceftazidime and povodine iodine gel. 2 days after biopsy, all patients were investigated about significant fever(eâ³38Â°C). febrile patients were referred to urology clinic for further evaluation about acute prostatitis or septicemia. There was 210 patients in group A and 202 patients in group B. No significant difference was detected in mean age, prostatic volume, serum PSA level, re-biopsy rate and pathology report between two groups. Acute prostatitis was developed in 2 patients (0.9) in group A and 1 patient (0.5) in group B that was not statistically significant.(P>0.05) Removing amikacin from ciprofloxacin-based antibiotic prophylaxis along with local povodine iodine would not put our patients in increased risk for infectious complications after TRUSBx. Â© 2016, Oriental Scientific Publishing Company. All rights reserved.

Acute Prostatitis After Transrectal Ultrasound-guided Prostate Biopsy: Comparing Two Different Antibiotic Prophylaxis Regimen