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Cardiovascular diseases and atherosclerosis that develops through gradual fatty deposits in the lower part of vascular endothelium are the main causes of death in the world. This research intended to study the effects of hydroalcoholic extract of valerian on the quantity of lipoproteins and on the development of atherosclerosis in the aortas of male hypercholesterolemic rabbits. This empirical research was carried out on 30 male New Zealand rabbits that were divided into 5 groups each with 6 members. The control group received no medicine. Sham group one were given 10 ml of corn oil (a cholesterol solvent) every day, sham group two 10 ml of cholesterol every day, and the experimental groups one and two 50 and 200 ml of hydroalcoholic extract of valerian, respectively. At the completion of the research, the data was analyzed using ANOVA and Duncan’s test, and Excel was employed to draw the figures. Concentrations of HDL, LDL, and triglycerides in the cholesterol sham group increased significantly compared to the control group, but significantly decreased in the experimental groups compared to the cholesterol sham group. Valerian improves HDL, LDL, and triglyceride levels in male hypercholesterolemic rabbits.

Hydroalcoholic Extract of Valerian, Blood Factors, and Atherosclerotic Plaque Formation in Male Hypercholesterolemic Rabbits