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Chronic Periodontitis, an inflammatory disease caused by oral bacteria stimulates the host cells, neutrophils which release Reactive Oxygen Species(ROS) as a part of immune response. Diabetes Mellitus is a complex disease with varying degrees of systemic and oral complications. The study population consisted of 40 subjects belonging to both sexes were randomly selected. Subjects were divided into two groups, Chronic Periodontitis(CP), ( Group I) and Chronic Periodontitis with Diabetes Mellitus (CP-DM), (Group II).GCF, saliva and plasma were collected in all the two groups to estimate the Reactive oxygen metabolites levels. The values obtained in GCF were significant[ pvalue 0.001]and the ROM levels in saliva and plasma were significantly higher in Chronic Periodontitis with Diabetes Mellitus group compared to Chronic Periodontitis [ pvalue < 0.001] .The results of our study suggested that a significant oxidative stress may occur in Chronic Periodontitis with Diabetic Mellitus patients which supports the etiological role of free radical injury .

biomedical and pharmacology journal/biomedical and pharmacology journal

Prevalence of Reactive Oxygen Metabolites Levels in Chronic Periodontitis with Diabetic Mellitus and Chronic Periodontitis Patients in GCF, Plasma and Saliva: A Biochemical Study