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Cutaneous adverse drug reactions (CADRs) are common, comprise approximately 2-3% of all the ADRs. Most of them are mild, self-limiting. Severe and potentially life-threatening eruptions occur in approximately 1 in 1000 hospitalised patients. Which carry a high degree of morbidity & mortality. Hence early detection, evaluation and monitoring of ADRs in particular CADRs are essential. As the pattern of CADRs is changing every year with the introduction of new medications & evolving prescription practices. To determine the pattern of various types of CADRs & to identify causative drug implicated in our setup, this study was carried out. A retrospective analysis of the CADRs retrieved from the Pharmacovigilance centre database, reported spontaneously between 25thAug 2015 to 31stOct 2019. The CADRs obtained were categorized according to their morphology & the suspected drugs were grouped according to ATC classification. Causality, severity & preventability assessment was done by using pretested scales. 70 patients had CADRs with male to female ratio of 1:2. Urticaria (37.14%) was the most common CADR & 5.7% of the CADRs were severe. Anti-infectives for systemic use (48.6%) was predominantly involved in the causation of CADRs. Most of the CADRs belong to a possible category, 75% of them were either recovered or recovering at the time of reporting & only 25% of the CADRs are preventable. Pattern of ACDRs & the drugs causing them are slightly different in our population as compared to other previous studies. Which emphasizes the need for robust ADR monitoring system in our setup.

biomedical and pharmacology journal/biomedical and pharmacology journal

A Study of Cutaneous Adverse Drug Reactions; Clinical/Morphological Pattern and Causative Agents Reported in an ADR Monitoring Centre in a Tertiary Care Hospital of North Karnataka