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In this review how the highly active antiretroviral therapy (HAART) damage the mitochondria, followed by immune activation and insulin resistance. The introduction and evolution of HAART over the past 25 years have brought an amazing decrease in AIDS-and immunodeficiency-related reasons for death. However, deaths of these people are now related to metabolic disorder diseases, including atherosclerotic cardiovascular diseases, before from the viral infection itself. Insulin resistance is at the root causes of maladies of metabolic related disorder diseases. While it is notable that HAART metabolism and immune activation cross taking contribute advancement of insulin resistance and co-morbid illnesses. The molecular mechanisms of HAART metabolism and insulin resist is not completely understand. Emerging evidence that HAART how induced mitochondrial damage? and exacerbates the inflammatory response which leads to the development of insulin resistance are remain largely unresolved. The clarification and comprehension of these mechanisms will offer ascent to new classes of medications for the management of insulin resistance that will additionally improve the quality of life of HIV-infected patients..

The Missing Link between HAART, Mitochondrial Damage and Insulin Resistance