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Sukun (Artocarpus altilis), the breadfruit, has been known to contain phytochemicals that have inhibitory activity against xanthine oxidase, however little is known about their efficacy in lowering uric acid levels. This study aims to determine the effect of water-soluble fraction of breadfruit leaf extract on blood uric acid levels in purine-rich food-induced mice. Twenty-five male mice received beef liver extract once daily for 7 days and were grouped into five. The first group receives only solvent as the normal control. At day 8, mice of first group were sacrificed for taking their blood and measuring its uric acid levels. As for the group 2, 3, and 4, in the period of day 8 to day 14, consecutively received sukun leaves extract at the dosage of 58.5, 117 and 234 mg/kg BW. Group 5 received allopurinol at the dose of 13 mg/kg BW as the positive control. At the day 15 all mice were sacrificed and their blood uric acid levels were determined. The results showed that the water fraction of sukun leaf extract significantly decreased blood uric acid levels of test mice. At the dose of 234 mg / kg BW the anti-hyperuricemic properties of the plant leaf extract equals the standard drug, the allopurinol.

Anti-Hyperuricemic Effects of Water-Soluble Fraction of Leaf Extract of Sukun (Artocarpus Altilis) on Mice Fed Purine-Rich Foods