English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Peptic ulcer disease is common diseases of the gastrointestinal tract that occur with long term use of NSAIDs. Currently available drugs for acid peptic disease shows side effects, relapses after discontinuation and drug interactions. Many Indian medicinal plants and their active compounds are used for prevention and treatment of Peptic ulcer.To evaluate the antiulcerogenic and anti-oxidant activity of Alpinia galanga rhizome in Wistar Albino rats.Animals were divided into 4 groups with 6 animals in each. Group 1 received only vehicle 1% CMC orally for 7 days. Group 2 received 1% Carboxyl methyl cellulose (gastric mucosal injury was induced by Indomethacin in this group) orally for 7 days. Group 3 received Alpinia galanga rhizomes extract (AGRE) 200 mg/kg orally for 7 days. Group 4 received Ranitidine 20 mg/kg orally. On 7th day, overnight fasted rats were given last dose of drugs and after 60 minutes of the last dose, gastric mucosal damage was produced by Indomethacin 40 mg/kg through gastric lavage, in all groups except group 1. Six hours later, calculation of ulcer score was done using Ulcer index and percentage inhibition method. The number and severity of ulcers were recorded with arbitrary scale. The antioxidant action of AGRE was also assessed.Rats pre-treated with extract of Alpinia galanga rhizomes showed significant decrease in ulcer index and percentage inhibition of ulcers was comparable with Ranitidine. Also, there was a significant increase in antioxidant levels in rats treated with Alpinia galanga rhizomes extract showing its antioxidant property.The extract shows significant antiulcer activity against Indomethacin induced gastric ulcers probably due to its antioxidant property.

biomedical and pharmacology journal/biomedical and pharmacology journal

Anti Ulcerogenic and Anti-Oxidant Activity of Alpinia Galanga Rhizomes Aqueous Extract in Indomethacin Induced Gastric Mucosal Damage in Wistar Albino Rats