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This breast cancer is a disease which is common in India with mortality incidence ratio of 66 in rural and 8 in urban. Breast cancer can be cured once it is diagnosed appropriately and when treatment is started at right time with right drug in proper dosage. But chemotherapy itself have many adverse events, to come over these problems, natural products or extracts are being used to aid in reducing the complications. To evaluate Anti-Cancer activity of piperine and tamoxifen and in both as Combination on the MCf 7 human breast cancer cell lines. Breast cancer cells (MCf 7) have been treated with piperine and incubated at 37 c, the drug samples were added, incubated for 3 hours then followed by tetrazolium dyetreatment and incubated. One ml of dimethyl sulfoxide is added and incubated. Absorbance at 537nm was measured with UV spectrophotometer using dimethyl sulfoxide as the blank. Then IC50 was determined in graphical representation according to percentage of cell viability and concentration of sample. The anti-cancer effect of piperine and tamoxifen and in Combination, when treated with MCf 7 human breast cancer cell lines, starting from minimum to maximum dose concentration (μg/ ml), the percentage of cell viability is 51.49 at the dose of 62.5 μg/ml, 51.09 at 125 μg/ml, 52 at the dose of 32.5 for piperine, tamoxifen and combination respectively. This study concludes tamoxifen in combination with piperine have significant anti-cancer activity, which would probably play a role as cytotoxic agent in tumour cells.

A Comparative Study On Viability Of Mcf-7 Human Breast Cancer Cell Lines Using Piperine And Tamoxifen – An In Vitro Study With A Novel Mishmash