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Biopolymers are used as basic compounds for design of scaffolds for different tissue engineering applications. Chitosan and sodium alginate have proven wound healing property individually. But the scaffolds prepared with single polymer have shown poor physicomechanical properties which are essential during handling, storage and application. Hence, the present study focused on development of composite scaffolds using chitosan and different concentrations of sodium alginate to enhance the physico mechanical properties and also loaded with lentil seed extract (LSE) to improve its wound healing property with the combination of antioxidant/antibacterial activities of LSE. The LSE loaded composite scaffolds were prepared with different concentrations of ethanolic extract of lentil seeds in selected best blank composite scaffolds. All the scaffolds were evaluated for various in vitro parameters like thickness, folding endurance, equilibrium swelling, antibacterial activity, tensile and texture parameters to confirm the suitability of prepared external combination. The wound healing activity was determined by in vivo studies using albino rats by estimating percentage wound contraction, histopathological properties, biochemical parameters and photography. As the concentration of sodium alginate was increased the mechanical properties of scaffolds were remarkably improved. The LSE loaded scaffolds shown significant difference in antibacterial and wound healing activity when compared to blank composite scaffolds. The present results revealed that LSE loaded prepared bioscaffolds possessed fast wound healing activity compared to blank scaffolds without losing its mechanical properties. The present study successfully designed a natural, biocompatible wound dressing at low cost for fast healing of wounds in animals and human beings.

Design and Evaluation of Lentil Seed Extract Loaded Bio Scaffolds for Wound Healing Activity