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Pedalium murex plant an Indian seasonal herb has been found to be effective against gonorrhoea, dysuria, reproductive disorders etc by some researchers. Studies also reported its hypoglycemic, antioxidant effect in rodents. One study proved the efficacy of petroleum ether extracts of P.murex dry seed (PEPM) against ethanol induced testicular dysfunction in albino rats. Testicular dysfunction with STZ induced diabetes mellitus is caused by uncontrolled hyperglycemia and oxidative stress. The present study aimed to evaluate the effect of petroleum ether extracts of P.murex dry seed (PEPM) on testicular dysfunction in STZ induced T2DM. The parameters evaluated are FBG level , tissue MDA and SOD level, seminal analysis and histopathological study of testis by Johnsen’s scoring. Thirty (30) wistar albino rats were randomly divided into 5 groups (n=6). Group1 (control), group-2 to group-5 were treated with single dose injection (i.p) of streptozotocin (40mg/ kg) for induction of diabetes mellitus. All the rats received differentdrugs for 60 days as follows: Group 1(Tween 80) Group2: Disease Control (Tween 80), Group3metformin (50 mg/kg), Group 4-PEPM (400 mg/kg) and Group 5-(PEPM)+ metformin (25mg/kg). On day 61, rats were sacrificed and FBG estimated, semen collected from caudal epididymis. Sperm count, motility, morphological abnormalities were noted by microscopic examination. Oxidative stress markers like MDA and SOD were estimated from testicular tissue homogenate. Histopathological examination of testis was done and scored by Johnsen’s score. All the data were analysed by One way ANOVA except Johnsen’s score which was analysed by Kruskal-Wallis test .P< 0.05 was considered significant. The normal rats received PEPM did not show any significant change in FBG. Diabetic control rats showed significant increase in FBG, alteration in testicular MDA level and SOD activity, decrease in sperm parameters and Johnsen’s score. Metformin, PEPM (400 mg/kg) and combination of PEPM+ metformin treated groups significantly reversed the above parameters. Petroleum ether extract of P.murex dry seed possess anti-hyperglycemic, antioxidant and germ-cell protective properties in STZ – T2DM rats.

Effect of Pedalium murex Dry Seed Extract on Testicular Dysfunction in Streptozocin Induced Diabetes Mellitus in Wistar Albino Rats