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ABSTRACT Diabetes Mellitus (DM) is a degenerative disease that threatens global health. According World Health Organisation (WHO), Indonesia ranks 4th largest number of people with diabetes. Diabetes is a chronic metabolic disorder due to pancreas can not produce enough insulin or body can not use insulin, causing increasing blood sugar levels. The active ingredients like tannin, polyphenolic and acarbose in herbs have potential efectiveness as an antidiabetic and antioxidant.These herbs are being into alternative treatments that are often used in society as diabetic treatment. This study uses soursop leaves, bay leaves, and pegagan leaves extract. The leaves will be tested effectiveness as an antidiabetic and antioxidant with measuring effectiveness of enzymatic inhibition of ±-amylase, ±-glukosidase and total phenolic, that can affect blood sugar and oxidative stress conditions whiches experienced by patients with DM. Test result showedthat total phenol content obtained highest titer in soursop leavessingle extract, followed by a mixture of soursop leaves and pegagan leaves extract and lowest total phenol content obtained at a single extract of bayleaves. The highest potential effectiveness of anti-±-amylase similar with anti ±-glucosidase obtained in a single extract of soursop leaves, followed by a mixture of soursop leaves and bay leaves extract and lowest potential was measured in single extractpegagan leaves and bay leaves. High effectiveness potential in herbs preparation as anti ±-amylase, anti ±-glucosidase, and antioxidant activity of total phenol content will treatand inhibit the progression of glucose metabolic disorder due to metabolic abnormalities in patients with DM. Keywords: anti α-amylase, anti α-glucosidase, antidiabetic, herbal mixture.

biomedical and pharmacology journal/biomedical and pharmacology journal

Comparison Effectiveness of Antidiabetic Activity Extract Herbal Mixture of Soursop Leaves(Annona muricata), Bay Leaves(Syzygium polyanthum) and Pegagan Leaves(Centella asiatica)