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Betatrophin is a secreted protein of 198 aa that promotes â cell proliferation. It is expressed in the, white and brown adipose tissue of mice. In humans, betatrophin is expressed in the liver. Evaluation the potency of betatrophin therapy as alternative treatment instead of insulin injection in mice with type1 diabetes. This experimental study was based on 30 mice, the study was carried out at animal house, college of medicine-University of Baghdad. These rats were provided from the animal house of medicine, pharmacology Colleges -University of Baghdad. These mice divided into three group’s first group are mice treated with insulin (10 mice), second group are mice treated with betatrophin (10 mice) and third group consider as a control group non-diabetic mice (10 mice). Plasma mice C-peptide concentration were measured using an enzyme-linked immunosorbent assay. Fasting blood glucose was measured by using colorimetric methods, these measurements was done in the Teaching laboratories of Baghdad Medicine Hospital. Level of fasting blood glucose show no significant differences among inducible type1 diabetic(T1DM) mice treated with insulin, inducible type1 diabetic(T1DM) mice treated with betatrophin and their control group (90.0 ± 10.8 ,75 ±12.9,85 ±17) mg/dl with p=0.016. That inducible type1 diabetic(T1DM) mice with betatrophin inj. treatment had higher significant mean of c-peptide (3.3±2.2ng/ml) than inducible type1 diabetic(T1DM) mice with insulin inj. Treatment (2.9 ± 0.8 ng/ml) but both groups had significant lower mean than control non-diabetic mice (5.3 ± 1.2 ng/ml). Data suggested that betatrophin is lower blood sugar and might be lower the dependence of diabetic patients on insulin injection treatment, but this study need for further work to say that betatrophin can replace the insulin treatment.

Impress of Betatrophin in The Treatment of Mice with Diabetes type 1