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Hemodynamic complications of regional anesthesia in patients with severe preeclampsia, has been faced challenges using of this approach.one way to overcome this problem is decreasing dosage of anesthetic drugs but this situation, can result in pain during surgery. The aim of our study is comparing spinal anesthesia with low and conventional doses of Bupivacaine on hemodynamic parameters in patient with severe preeclampsia whom underwent cesarean section. 60 patients with severe preeclampsia who underwent cesarean delivery included in this clinical trial study randomly. Spinal anesthesia was done with injection of 7.5 and 12 mg Bupivacaine in two groups. Mean of blood pressure and heart rate were recorded at the beginning of induction and then during each 5 min until end of surgery. Data were compared with t test and repeated measure. Mean of hemodynamic parameters were significantly decreased during surgery in both groups but between groups we have hadn’t significant differences. Low dose of bupivacaine is suitable for cesarean section. however incidence of hemodynamic change hadn’t significant difference versus conventional dose.

biomedical and pharmacology journal/biomedical and pharmacology journal

Comparison of Spinal Anesthesia with Low and Conventional Doses of Bupivacaine on Hemodynamic Changes in Severe Preeclampsic Patients Candidate for Cesarean Section