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Adiponectin gene (ADIPOQ) has association with circulatory adiponectin levels, metabolic disorders and type 2 diabetes mellitus (T2DM) in different population. We aimed to evaluate the relationship between SNP rs266729 in promoter region of ADIPOQ gene with T2DM patients, circulatory adiponectin levels and other clinical and anthropometric parameters in North Indian adult population. This case-control study was conducted on 300 subjects (150 T2DM and 150 healthy controls), aged between 25-75 years. Biochemical investigations performed included fasting and post prandial blood sugar level, lipid profile and serum creatinine. Glycated haemoglobin (HbA1c) and circulatory adiponectin levels were assayed using commercially available kits. PCRRFLP method was used for genotyping. Mean levels of various anthropometric and biochemical parameters were significantly higher in T2DM than healthy controls (p<0.001). The levels of circulatory adiponectin was found significantly lower in T2DM as compared to healthy controls (p=0.014). There was no significant association of CC and CG genotypes with T2DM patients (p=0.81). C and G allele frequencies of the rs266729 were also not significantly associated with T2DM cases as compared to healthy controls (p=0.23). It was observed that significant impact on circulatory adiponectin levels for rs266729 polymorphism with GG genotype having very low circulatory adiponectin level (p<0.001). There was no significant association of CC, CG genotype and C, G allele frequencies of rs266729 in with T2DM cases as compared to healthy controls. However, it was observed that GG genotype of rs266729 has significant impact on circulatory adiponectin levels in T2DM cases. The GG carrier females have two fold increased risk for diabetes than men.

biomedical and pharmacology journal/biomedical and pharmacology journal

Association of ADIPOQ Gene Variant rs266729 with Circulatory Adiponectin Levels in Patients with Type 2 Diabetes in North Indian Population: A Case-Control Study