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Chronic obstructive pulmonary disease (COPD) will restrict the airflow in an irreversible way. Periods of COPD exacerbation are filled with worse respiratory symptoms of patient along with dyspnea, coughing and phlegm. Using non-invasive mechanical ventilation (NIV) will reduce the long term treatment side effects, need for intubation and mortality. The present research seeks to investigate and compare the NIV with high and low inspiratory pressure in patients with COPD exacerbation. the present research is an interventional or clinical trial study conducted on a population of 40 people suffering from COPD Exacerbation over the period of years 2015-2016. These people were randomly placed in two groups of 20 people and NIV with high and low inspiratory pressure was taken into consideration for each group. Finally, the O2 saturation(O2 sat), number of breathes and ABG (Arterial Blood Gas) before and one hour after NIV was checked for all patients. the results indicated that both groups were similar in terms of their age and age had no effect on results (P-value = 0.3704). Low inspiratory pressure caused significant changes in PH (P-value = 0.028) and respiratory rate (P-value = 0.0178). Meanwhile, all the factors studied exhibited significant changes under high inspiratory pressure. It was also shown that a significant difference would be caused between the two groups in terms of changes in CO2, PH, SO2, and respiratory rate factors that favor high inspiratory pressure. the results of this study showed that using high inspiratory pressure for patients suffering from COPD Exacerbation will improve factors of CO2, HCO3, PH, SO2, and respiratory rate when compared to using low inspiratory pressure. This fact is indicative of superiority of NIV therapeutic strategy with high inspiratory pressure.

biosciences biotechnology research asia/biosciences biotechnology research asia

Comparing and Investigating the Effects of Bi-level Non-Invasive Ventilator with High and Low Inspiratory Pressure in a Group of Patients Suffering from COPD Exacerbation over the Period of 2015-2016