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Objective: This study aims to investigate the role of oxidative stress congenital heart defects with left - to - right shunt by determining total oxidant status (TOS), total antioxidant status and oxidative stress index (OSI) in affected children. Methods: This is a prospective, randomized case - control study which reviews 40 hea lthy children and 40 children who have congenital heart defects with left - to - right shunt. Results: The healthy children and the children who have congenital heart defects with left - to - right shunt are statistically similar with respect to age, sex, height, weight and body mass index (p>0.05 for all). Both groups have statistically similar echocardiography findings including interventricular septum thickness, left ventricular internal diameter, left ventricular posterior wall, systolic volume, end diastolic v olume, fractional shortening, ejection fraction and left ventricular mass values (p>0.05 for each). These groups are also statistically similar in aspect of myocardial performance index, E´, A´, S´, relaxation time and contraction time values that have bee n specified for left ventricle, interventricular septum and right ventricle (p>0.05 for each). The healthy children and the children with congenital heart defects have statistically similar blood count parameters as well as serum concentrations of vitamin D and brain natriuretic peptide. The children who have congenital heart defects with left - to - right shunt have significantly higher TOS and OSI values than those of the healthy children (respectively, 35.6±2.8 nmol H 2 O 2 equiv/mg protein vs 16.1±4.6 nmol H 2 O 2 equiv/mg protein , p=0.018 and 32.4±1.4 vs 11.5±3.2, p=0.022 ). Conclusion: The imbalance between the prooxidant and antioxidant reactions causes an enhancement in oxidative stress which may contribute to the pathogenesis of congenital heart defects with left - to - right shunting.

The Oxidative Status of Children with Acyanotic Congenital Heart Diseases: A Randomized Controlled Study